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Nickel in PDB 1hyo: Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid

Enzymatic activity of Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid

All present enzymatic activity of Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid:
3.7.1.2;

Protein crystallography data

The structure of Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid, PDB code: 1hyo was solved by R.L.Bateman, P.Bhanumoorthy, J.F.Witte, R.W.Mcclard, M.Grompe, D.E.Timm, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 27.00 / 1.30
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 64.102, 109.458, 67.459, 90.00, 102.37, 90.00
R / Rfree (%) 18.1 / 19.9

Other elements in 1hyo:

The structure of Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms
Calcium (Ca) 2 atoms

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid (pdb code 1hyo). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid, PDB code: 1hyo:

Nickel binding site 1 out of 1 in 1hyo

Go back to Nickel Binding Sites List in 1hyo
Nickel binding site 1 out of 1 in the Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Fumarylacetoacetate Hydrolase Complexed with 4-(Hydroxymethylphosphinoyl)-3-Oxo-Butanoic Acid within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni1008

b:14.1
occ:1.00
 O B:HOH1319 2.3 17.1 1.0
O B:HOH1272 2.3 17.5 1.0
O B:HOH1320 2.4 21.2 1.0
O B:GLY499 2.4 19.9 1.0
N B:GLY499 2.7 24.6 1.0
C B:GLY499 3.1 18.3 1.0
CA B:GLY499 3.3 19.2 1.0
O B:HOH1280 4.1 26.1 1.0
O B:HOH1286 4.2 28.6 1.0
N B:SER500 4.3 16.3 1.0
O B:HOH1416 4.7 25.4 1.0
O B:HOH1377 4.8 28.7 1.0

Reference:

R.L.Bateman, P.Bhanumoorthy, J.F.Witte, R.W.Mcclard, M.Grompe, D.E.Timm. Mechanistic Inferences From the Crystal Structure of Fumarylacetoacetate Hydrolase with A Bound Phosphorus-Based Inhibitor. J.Biol.Chem. V. 276 15284 2001.
ISSN: ISSN 0021-9258
PubMed: 11154690
DOI: 10.1074/JBC.M007621200
Page generated: Wed Oct 9 14:56:57 2024

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