Nickel in the structure of Rat Dihydroorotate Dehydrogenase (Dhod)in Complex With Brequinar (pdb 1uuo)

The binding sites of Nickel atom in the structure of Rat Dihydroorotate Dehydrogenase (Dhod)in Complex With Brequinar (pdb code 1uuo). This binding sites where shown with 5.0 Angstroms radius around Nickel atom. The 1uuo structure was solved by M.HANSEN, J.LE NOURS, E.JOHANSSON, T.ANTAL, A.ULLRICH, M.LOFFLER, S.LARSEN, with X-Ray Crystallography technique, brief refinement statistics is given in the table below: Resolution (A) 20.0-2.4 Space group C2221 a (A) 49.753 b (A) 95.801 c (A) 144.469 alpha (°) 90.00 beta (°) 90.00 gamma (°) 90.00 Rfactor (%) 21 Rfree (%) 26.3 Nickel Binding Sites: Nickel binding site 1 out of 1 in 1uuo Click to enlarge Click to enlarge Mono- and Stereo- picture of 5.0 Angstrom coordination sphere 1 of Nickel in the PDB 1uuo. Coordination sphere was calculated for all residues within 5.0 Angstroms distance from the central Nickel atom, shown by VdW sphere Residues shown as a stick model or VDW spheres: A: Gly203, A: Pro204, A: Leu205, A: Ala206, A: Asp207, A: Thr247, A: Arg248, A: Lys249, A: Pro250, conact list: Atom Atom Distance (A) Ni O A:Gly203 3.01 Ni C A:Gly203 4.14 Ni O A:Pro204 3.45 Ni N A:Pro204 4.62 Ni C A:Pro204 3.73 Ni CA A:Pro204 4.10 Ni N A:Leu205 4.39 Ni C A:Leu205 4.58 Ni CA A:Leu205 4.87 Ni O A:Ala206 2.74 Ni N A:Ala206 4.08 Ni C A:Ala206 3.85 Ni CA A:Ala206 4.51 Ni N A:Asp207 4.88 Ni CB A:Thr247 4.46 Ni CG2 A:Thr247 4.85 Ni OG1 A:Thr247 3.11 Ni C A:Thr247 4.85 Ni O A:Arg248 2.68 Ni N A:Arg248 4.08 Ni CB A:Arg248 4.41 Ni C A:Arg248 3.81 Ni CA A:Arg248 4.35 Ni N A:Lys249 4.92 Ni C A:Lys249 4.97 Ni N A:Pro250 4.55 Ni CB A:Pro250 4.48 Ni CD A:Pro250 4.24 Ni CG A:Pro250 4.73 Ni CA A:Pro250 4.93 interactive model: