Nickel in PDB 2c9w: Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution

The structure of Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution, PDB code: 2c9w was solved by J.E.Debreczeni, A.Bullock, A.Amos, P.Savitsky, A.Barr, N.Burgess, M.Sundstrom, J.Weigelt, C.Arrowsmith, A.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	91.29 / 1.90
Space group	P 32 2 1
Cell size a, b, c (Å), α, β, γ (°)	105.290, 105.290, 70.200, 90.00, 90.00, 120.00
R / Rfree (%)	18.5 / 22.5

The binding sites of Nickel atom in the Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution (pdb code 2c9w). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 3 binding sites of Nickel where determined in the Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution, PDB code: 2c9w:
Jump to Nickel binding site number: 1; 2; 3;

Nickel binding site 1 out of 3 in the Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni1202 b:74.0 occ:1.00 ND1 A:HIS124 3.3 44.3 1.0 N A:ASP120 3.6 32.2 1.0 CB A:ASP120 3.9 35.8 1.0 CE1 A:HIS124 3.9 46.3 1.0 O A:HOH2053 4.1 41.4 1.0 N A:SER121 4.2 35.6 1.0 CA A:ASP120 4.3 35.6 1.0 CA A:PHE119 4.3 35.7 1.0 C A:PHE119 4.4 35.0 1.0 CG A:HIS124 4.5 38.9 1.0 CB A:PHE119 4.6 36.8 1.0 CG A:ASP120 4.7 46.6 1.0 CD2 A:PHE119 4.7 34.9 1.0 C A:ASP120 4.8 34.3 1.0 CB A:SER121 4.8 33.5 1.0 CB A:HIS124 4.8 31.1 1.0

Nickel binding site 2 out of 3 in the Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni1203 b:33.8 occ:0.75 SG A:CYS111 2.1 37.0 1.0 CB A:CYS111 3.1 40.3 1.0 CA A:CYS111 3.8 43.6 1.0 N A:CYS111 4.4 41.4 1.0 CG2 A:ILE110 4.7 41.0 1.0 NE2 A:HIS149 4.7 72.9 1.0 O A:ILE110 4.7 43.3 1.0 C A:ILE110 4.8 40.5 1.0 O A:HOH2049 4.9 47.6 1.0 CD2 A:LEU95 5.0 39.0 1.0

Nickel binding site 3 out of 3 in the Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Crystal Structure of Socs-2 in Complex with Elongin-B and Elongin-C at 1.9A Resolution within 5.0Å range: probe atom residue distance (Å) B Occ B:Ni1105 b:47.2 occ:0.50 SG B:CYS89 2.3 48.4 1.0 CB B:CYS89 3.1 39.9 1.0 C B:CYS89 3.7 37.4 1.0 O B:CYS89 3.8 35.8 1.0 CA B:CYS89 3.9 36.7 1.0 N B:ILE90 4.0 34.0 1.0 CA B:HIS10 4.1 32.6 1.0 N B:GLU91 4.2 32.4 1.0 CD2 B:HIS10 4.2 34.2 1.0 C B:ILE90 4.3 33.2 1.0 CG B:HIS10 4.3 32.7 1.0 CA B:ILE90 4.5 33.2 1.0 OE1 B:GLU91 4.5 49.6 1.0 CA B:GLU91 4.6 36.0 1.0 CB B:HIS10 4.6 31.9 1.0 O B:ILE90 4.7 33.2 1.0 NE2 B:HIS10 4.7 28.8 1.0 CB B:GLU91 4.7 36.4 1.0 ND1 B:HIS10 4.8 33.7 1.0 N B:HIS10 4.9 32.4 1.0 C B:HIS10 5.0 32.2 1.0

A.N.Bullock, J.E.Debreczeni, A.M.Edwards, M.Sundstrom, S.Knapp. Crystal Structure of the SOCS2-Elongin C-Elongin B Complex Defines A Prototypical Socs Box Ubiquitin Ligase. Proc. Natl. Acad. Sci. V. 103 7637 2006U.S.A..
ISSN: ISSN 0027-8424
PubMed: 16675548
DOI: 10.1073/PNAS.0601638103