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Nickel in PDB 2cg5: Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A

Enzymatic activity of Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A

All present enzymatic activity of Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A:
1.2.1.31; 2.3.1.85;

Protein crystallography data

The structure of Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A, PDB code: 2cg5 was solved by G.Bunkoczi, A.Joshi, E.Papagrigoriu, C.Arrowsmith, A.Edwards, M.Sundstrom, J.Weigelt, F.Von Delft, S.Smith, U.Oppermann, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 50.00 / 2.70
Space group P 32 2 1
Cell size a, b, c (Å), α, β, γ (°) 69.361, 69.361, 184.715, 90.00, 90.00, 120.00
R / Rfree (%) 19.2 / 24.7

Other elements in 2cg5:

The structure of Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A also contains other interesting chemical elements:

Magnesium (Mg) 2 atoms

Nickel Binding Sites:

The binding sites of Nickel atom in the Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A (pdb code 2cg5). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A, PDB code: 2cg5:

Nickel binding site 1 out of 1 in 2cg5

Go back to Nickel Binding Sites List in 2cg5
Nickel binding site 1 out of 1 in the Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Structure of Aminoadipate-Semialdehyde Dehydrogenase- Phosphopantetheinyl Transferase in Complex with Cytosolic Acyl Carrier Protein and Coenzyme A within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1302

b:63.9
occ:0.50
 N A:GLY149 3.3 58.2 1.0
NH1 B:ARG2138 3.5 56.5 1.0
ND1 B:HIS2133 3.5 53.3 1.0
O A:HOH2011 3.5 47.8 1.0
CA A:ARG148 3.9 58.7 1.0
C A:ARG148 4.1 58.2 1.0
O A:GLY147 4.1 59.1 1.0
CA A:GLY149 4.2 57.7 1.0
CE1 B:HIS2133 4.2 54.2 1.0
O A:HOH2010 4.3 44.8 1.0
CG B:HIS2133 4.5 54.0 1.0
CZ B:ARG2138 4.6 55.7 1.0
CB A:ARG148 4.6 59.1 1.0
O A:HOH2013 4.7 54.3 1.0
CB B:HIS2133 4.7 54.3 1.0
N A:ARG148 4.8 58.7 1.0
C A:GLY147 4.8 58.8 1.0
NH2 B:ARG2138 4.9 56.1 1.0
CG A:ARG148 4.9 60.8 1.0
O A:GLY149 4.9 58.1 1.0
C A:GLY149 5.0 57.7 1.0

Reference:

G.Bunkoczi, S.Pasta, A.Joshi, X.Wu, K.L.Kavanagh, S.Smith, U.Oppermann. Mechanism and Substrate Recognition of Human Holo Acp Synthase. Chem.Biol. V. 14 1243 2007.
ISSN: ISSN 1074-5521
PubMed: 18022563
DOI: 10.1016/J.CHEMBIOL.2007.10.013
Page generated: Wed Oct 9 16:41:28 2024

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