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Nickel in PDB 2nz6: Crystal Structure of the Ptprj Inactivating Mutant C1239S

Enzymatic activity of Crystal Structure of the Ptprj Inactivating Mutant C1239S

All present enzymatic activity of Crystal Structure of the Ptprj Inactivating Mutant C1239S:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of the Ptprj Inactivating Mutant C1239S, PDB code: 2nz6 was solved by E.Ugochukwu, A.Barr, P.Savitsky, A.C.W.Pike, G.Bunkoczi, M.Sundstrom, J.Weigelt, C.H.Arrowsmith, A.Edwards, F.Von Delft, S.Knapp, Structuralgenomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 46.98 / 2.30
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 88.521, 88.521, 118.950, 90.00, 90.00, 120.00
R / Rfree (%) 18.2 / 22.8

Other elements in 2nz6:

The structure of Crystal Structure of the Ptprj Inactivating Mutant C1239S also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of the Ptprj Inactivating Mutant C1239S (pdb code 2nz6). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 5 binding sites of Nickel where determined in the Crystal Structure of the Ptprj Inactivating Mutant C1239S, PDB code: 2nz6:
Jump to Nickel binding site number: 1; 2; 3; 4; 5;

Nickel binding site 1 out of 5 in 2nz6

Go back to Nickel Binding Sites List in 2nz6
Nickel binding site 1 out of 5 in the Crystal Structure of the Ptprj Inactivating Mutant C1239S


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of the Ptprj Inactivating Mutant C1239S within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni201

b:17.2
occ:0.33
 NE2 A:HIS-16 2.2 21.7 1.0
NE2 A:HIS-18 2.3 16.9 1.0
CE1 A:HIS-16 3.0 21.6 1.0
CE1 A:HIS-18 3.1 18.8 1.0
CD2 A:HIS-16 3.2 20.0 1.0
CD2 A:HIS-18 3.4 18.6 1.0
ND1 A:HIS-16 4.2 22.2 1.0
ND1 A:HIS-18 4.3 16.4 1.0
CG A:HIS-16 4.3 21.8 1.0
CG A:HIS-18 4.5 17.4 1.0

Nickel binding site 2 out of 5 in 2nz6

Go back to Nickel Binding Sites List in 2nz6
Nickel binding site 2 out of 5 in the Crystal Structure of the Ptprj Inactivating Mutant C1239S


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of the Ptprj Inactivating Mutant C1239S within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni203

b:58.1
occ:1.00
 NE2 A:HIS1206 2.3 34.5 1.0
CD2 A:HIS1206 3.2 34.8 1.0
CE1 A:HIS1206 3.3 33.9 1.0
OD2 A:ASP1205 4.3 40.2 1.0
CG A:HIS1206 4.4 34.4 1.0
ND1 A:HIS1206 4.4 33.6 1.0
CG A:ASP1205 4.9 37.0 1.0

Nickel binding site 3 out of 5 in 2nz6

Go back to Nickel Binding Sites List in 2nz6
Nickel binding site 3 out of 5 in the Crystal Structure of the Ptprj Inactivating Mutant C1239S


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Crystal Structure of the Ptprj Inactivating Mutant C1239S within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni204

b:24.1
occ:1.00
 ND1 A:HIS-20 1.9 26.1 1.0
N A:HIS-20 2.0 23.2 1.0
N A:HIS-21 2.1 22.8 1.0
C A:HIS-21 2.8 22.8 1.0
CG A:HIS-20 2.9 24.3 1.0
CA A:HIS-21 2.9 22.9 1.0
CE1 A:HIS-20 2.9 25.9 1.0
CA A:HIS-20 3.1 23.2 1.0
CB A:HIS-20 3.2 23.2 1.0
N A:HIS-19 3.6 21.7 1.0
C A:HIS-20 3.8 22.6 1.0
CD2 A:HIS-20 4.0 24.0 1.0
O A:HIS-21 4.0 23.6 1.0
NE2 A:HIS-20 4.0 26.4 1.0
CB A:HIS-21 4.1 23.1 1.0
CG A:HIS-21 4.1 21.6 1.0
CD2 A:HIS-21 4.2 19.6 1.0
CA A:HIS-19 4.8 21.6 1.0
ND1 A:HIS-21 4.9 23.6 1.0
O A:HIS-20 5.0 22.4 1.0
CB A:HIS-19 5.0 21.5 1.0
NE2 A:HIS-21 5.0 21.9 1.0

Nickel binding site 4 out of 5 in 2nz6

Go back to Nickel Binding Sites List in 2nz6
Nickel binding site 4 out of 5 in the Crystal Structure of the Ptprj Inactivating Mutant C1239S


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 4 of Crystal Structure of the Ptprj Inactivating Mutant C1239S within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni205

b:20.9
occ:1.00
 NE2 A:HIS-17 2.2 17.2 1.0
NE2 A:HIS-19 2.4 25.9 1.0
CE1 A:HIS-17 3.1 18.8 1.0
CD2 A:HIS-19 3.3 24.0 1.0
CD2 A:HIS-17 3.3 19.9 1.0
CE1 A:HIS-19 3.3 24.4 1.0
ND1 A:HIS-17 4.2 18.3 1.0
CG A:HIS-17 4.4 20.9 1.0
ND1 A:HIS-19 4.4 22.2 1.0
CG A:HIS-19 4.4 23.3 1.0

Nickel binding site 5 out of 5 in 2nz6

Go back to Nickel Binding Sites List in 2nz6
Nickel binding site 5 out of 5 in the Crystal Structure of the Ptprj Inactivating Mutant C1239S


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 5 of Crystal Structure of the Ptprj Inactivating Mutant C1239S within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni206

b:25.7
occ:0.33
 NE2 A:HIS-20 2.0 26.4 1.0
O A:HOH96 2.5 24.9 1.0
CD2 A:HIS-20 3.0 24.0 1.0
CE1 A:HIS-20 3.1 25.9 1.0
ND1 A:HIS-20 4.1 26.1 1.0
CG A:HIS-20 4.1 24.3 1.0

Reference:

A.J.Barr, E.Ugochukwu, W.H.Lee, O.N.King, P.Filippakopoulos, I.Alfano, P.Savitsky, N.A.Burgess-Brown, S.Muller, S.Knapp. Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.) V. 136 352 2009.
ISSN: ISSN 0092-8674
PubMed: 19167335
DOI: 10.1016/J.CELL.2008.11.038
Page generated: Wed Oct 9 16:51:58 2024

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