Nickel in PDB 2r36: Crystal Structure of Ni Human Arg-Insulin

The structure of Crystal Structure of Ni Human Arg-Insulin, PDB code: 2r36 was solved by R.Sreekanth, V.Pattabhi, S.S.Rajan, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	35.20 / 2.00
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	83.953, 83.953, 40.222, 90.00, 90.00, 120.00
R / Rfree (%)	22.1 / 25.5

The structure of Crystal Structure of Ni Human Arg-Insulin also contains other interesting chemical elements:

Chlorine	(Cl)	1 atom
Sodium	(Na)	1 atom

The binding sites of Nickel atom in the Crystal Structure of Ni Human Arg-Insulin (pdb code 2r36). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 4 binding sites of Nickel where determined in the Crystal Structure of Ni Human Arg-Insulin, PDB code: 2r36:
Jump to Nickel binding site number: 1; 2; 3; 4;

Nickel binding site 1 out of 4 in the Crystal Structure of Ni Human Arg-Insulin


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Ni Human Arg-Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Ni31 b:34.8 occ:0.33 NE2 B:HIS10 2.2 18.3 1.0 O B:HOH57 2.3 49.1 0.3 O B:HOH56 2.9 46.3 1.0 CE1 B:HIS10 3.1 29.0 1.0 CD2 B:HIS10 3.3 12.1 1.0 ND1 B:HIS10 4.3 28.7 1.0 CG B:HIS10 4.4 22.8 1.0

Nickel binding site 2 out of 4 in the Crystal Structure of Ni Human Arg-Insulin


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of Ni Human Arg-Insulin within 5.0Å range: probe atom residue distance (Å) B Occ D:Ni31 b:34.9 occ:0.33 NE2 D:HIS10 2.4 27.6 1.0 O D:HOH45 2.5 46.2 0.3 CL D:CL41 2.7 49.7 0.3 CE1 D:HIS10 3.3 11.6 1.0 CD2 D:HIS10 3.4 12.2 1.0 ND1 D:HIS10 4.4 16.4 1.0 CG D:HIS10 4.5 24.4 1.0

Nickel binding site 3 out of 4 in the Crystal Structure of Ni Human Arg-Insulin


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Crystal Structure of Ni Human Arg-Insulin within 5.0Å range: probe atom residue distance (Å) B Occ D:Ni32 b:32.9 occ:0.50 NE2 D:HIS5 2.8 40.2 1.0 CD2 D:HIS5 3.7 26.1 1.0 CE1 D:HIS5 3.8 29.9 1.0 ND1 D:HIS5 4.9 37.5 1.0 CG D:HIS5 4.9 29.7 1.0

Nickel binding site 4 out of 4 in the Crystal Structure of Ni Human Arg-Insulin


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 4 of Crystal Structure of Ni Human Arg-Insulin within 5.0Å range: probe atom residue distance (Å) B Occ B:Ni32 b:41.1 occ:0.50 NE2 B:HIS5 2.6 43.3 1.0 CD2 B:HIS5 3.2 32.1 1.0 O B:HOH58 3.4 45.3 1.0 CE1 B:HIS5 3.7 37.7 1.0 CG B:HIS5 4.5 33.6 1.0 O A:HOH28 4.6 67.3 1.0 ND1 B:HIS5 4.7 38.4 1.0

R.Sreekanth, V.Pattabhi, S.S.Rajan. Metal Induced Structural Changes Observed in Hexameric Insulin Int.J.Biol.Macromol. V. 44 29 2009.
ISSN: ISSN 0141-8130
PubMed: 18977386
DOI: 10.1016/J.IJBIOMAC.2008.09.019