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Nickel in PDB 3e7v: Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand

Enzymatic activity of Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand

All present enzymatic activity of Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand:
2.7.11.1;

Protein crystallography data

The structure of Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand, PDB code: 3e7v was solved by P.Filippakopoulos, J.Eswaran, T.Keates, N.Burgess-Brown, O.Fedorov, A.C.W.Pike, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, M.Wickstroem, C.Bountra, S.Knapp, Structural Genomics Consortium (Sgc), with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 25.44 / 2.00
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 78.497, 86.952, 68.460, 90.00, 90.00, 90.00
R / Rfree (%) 16.8 / 22.5

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand (pdb code 3e7v). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand, PDB code: 3e7v:

Nickel binding site 1 out of 1 in 3e7v

Go back to Nickel Binding Sites List in 3e7v
Nickel binding site 1 out of 1 in the Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni799

b:53.2
occ:1.00
O A:HOH968 2.3 40.8 1.0
NE2 A:HIS477 2.3 39.2 1.0
NE2 A:HIS563 2.4 24.4 1.0
O A:HOH831 2.4 43.6 1.0
CD2 A:HIS563 3.0 31.0 1.0
CD2 A:HIS477 3.2 41.1 1.0
CE1 A:HIS477 3.3 49.8 1.0
CE1 A:HIS563 3.6 21.7 1.0
O A:HOH992 3.6 54.5 1.0
CG A:HIS563 4.3 24.6 1.0
ND1 A:HIS477 4.4 40.0 1.0
CG A:HIS477 4.4 37.6 1.0
ND1 A:HIS563 4.5 21.9 1.0

Reference:

P.Filippakopoulos, J.Eswaran, T.Keates, N.Burgess-Brown, O.Fedorov, A.C.W.Pike, F.Von Delft, C.H.Arrowsmith, A.M.Edwards, M.Wickstroem, C.Bountra, S.Knapp. Crystal Structure of Human Haspin with A Pyrazolo-Pyrimidine Ligand To Be Published.
Page generated: Fri Sep 25 08:21:34 2020
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