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Atomistry » Nickel » PDB 3nbk-3qsf » 3oni » |
Nickel in PDB 3oni: Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1Protein crystallography data
The structure of Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1, PDB code: 3oni
was solved by
P.Filippakopoulos,
S.Picaud,
O.Fedorov,
F.Von Delft,
C.H.Arrowsmith,
A.M.Edwards,
J.Weigelt,
C.Bountra,
J.E.Bradner,
Structural Genomicsconsortium (Sgc),
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 3oni:
The structure of Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1 also contains other interesting chemical elements:
Nickel Binding Sites:
The binding sites of Nickel atom in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1
(pdb code 3oni). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1, PDB code: 3oni: Jump to Nickel binding site number: 1; 2; Nickel binding site 1 out of 2 in 3oniGo back to Nickel Binding Sites List in 3oni
Nickel binding site 1 out
of 2 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1
Mono view Stereo pair view
Nickel binding site 2 out of 2 in 3oniGo back to Nickel Binding Sites List in 3oni
Nickel binding site 2 out
of 2 in the Crystal Structure of the Second Bromodomain of Human BRD2 in Complex with the Inhibitor JQ1
Mono view Stereo pair view
Reference:
P.Filippakopoulos,
J.Qi,
S.Picaud,
Y.Shen,
W.B.Smith,
O.Fedorov,
E.M.Morse,
T.Keates,
T.T.Hickman,
I.Felletar,
M.Philpott,
S.Munro,
M.R.Mckeown,
Y.Wang,
A.L.Christie,
N.West,
M.J.Cameron,
B.Schwartz,
T.D.Heightman,
N.La Thangue,
C.A.French,
O.Wiest,
A.L.Kung,
S.Knapp,
J.E.Bradner.
Selective Inhibition of Bet Bromodomains. Nature V. 468 1067 2010.
Page generated: Wed Dec 16 01:26:45 2020
ISSN: ISSN 0028-0836 PubMed: 20871596 DOI: 10.1038/NATURE09504 |
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