Nickel in PDB 4cwd: Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate

Enzymatic activity of Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate

All present enzymatic activity of Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate:
1.14.11.1;

Protein crystallography data

The structure of Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate, PDB code: 4cwd was solved by M.A.Mcdonough, G.Kochan, A.Rydzik, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	24.826 / 1.90
*Space group*	H 3 2
*Cell size a, b, c (Å), α, β, γ (°)*	106.518, 106.518, 205.347, 90.00, 90.00, 120.00
*R / R_free (%)*	16.74 / 20.62

Other elements in 4cwd:

The structure of Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate (pdb code 4cwd). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate, PDB code: 4cwd:

Nickel binding site 1 out of 1 in 4cwd

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Nickel Binding Sites List in 4cwd

Nickel binding site 1 out of 1 in the Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate

Mono view

Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Human Gamma-Butyrobetaine,2- Oxoglutarate in Complex with 449, A Novel Substrate within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ni388 b:0.3 occ:1.00	NE2	A:HIS347	2.1	25.6	1.0
	OD1	A:ASP204	2.1	20.2	1.0
	O2'	A:OGA1386	2.2	39.0	1.0
	NE2	A:HIS202	2.2	22.1	1.0
	O2	A:OGA1386	2.4	34.8	1.0
	O	A:HOH2274	2.6	34.4	1.0
	C1	A:OGA1386	2.8	36.0	1.0
	C2	A:OGA1386	2.8	36.4	1.0
	CE1	A:HIS347	2.9	23.4	1.0
	CG	A:ASP204	3.0	21.2	1.0
	CD2	A:HIS347	3.1	24.6	1.0
	CD2	A:HIS202	3.1	19.4	1.0
	CE1	A:HIS202	3.2	20.2	1.0
	OD2	A:ASP204	3.3	21.5	1.0
	O1	A:OGA1386	3.9	36.0	1.0
	ND1	A:HIS347	4.0	24.6	1.0
	CG	A:HIS347	4.1	24.0	1.0
	OE1	A:GLN215	4.2	30.6	1.0
	N1	A:OGA1386	4.2	32.2	1.0
	ND1	A:HIS202	4.3	19.1	1.0
	CG	A:HIS202	4.3	18.2	1.0
	O	A:HOH2271	4.3	27.9	1.0
	CB	A:ASP204	4.4	18.5	1.0
	NE2	A:GLN215	4.4	25.7	1.0
	CD	A:GLN215	4.7	26.9	1.0
	CA	A:ASP204	4.7	16.6	1.0
	C4	A:OGA1386	4.8	30.4	1.0
	CAD	A:4491385	4.8	19.8	1.0
	N	A:ASP204	4.8	17.9	1.0
	CAC	A:4491385	4.9	21.8	1.0

Reference:

A.M.Rydzik, I.K.H.Leung, G.T.Kochan, M.A.Mcdonough, T.D.W.Claridge, C.J.Schofield. Oxygenase-Catalyzed Desymmetrization of N,N-Dialkyl- Piperidine-4-Carboxylic Acids. Angew.Chem.Int.Ed.Engl. V. 53 10925 2014.
ISSN: ISSN 1433-7851
PubMed: 25164544
DOI: 10.1002/ANIE.201406125

Page generated: Wed Dec 16 01:29:21 2020

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