Nickel in PDB 4idz: Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog)

The structure of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog), PDB code: 4idz was solved by W.S.Aik, M.A.Mcdonough, C.J.Schofield, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	26.54 / 2.46
Space group	H 3
Cell size a, b, c (Å), α, β, γ (°)	140.412, 140.412, 83.447, 90.00, 90.00, 120.00
R / Rfree (%)	19.4 / 24.5

The binding sites of Nickel atom in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog) (pdb code 4idz). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog), PDB code: 4idz:

Nickel binding site 1 out of 1 in the Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog)


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of the Human Fat Mass and Obesity Associated Protein (Fto) in Complex with N-Oxalylglycine (Nog) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni603 b:48.5 occ:1.00 NE2 A:HIS307 2.0 40.6 1.0 NE2 A:HIS231 2.0 41.0 1.0 O A:HOH702 2.1 32.5 1.0 O2' A:OGA601 2.1 45.9 1.0 OD1 A:ASP233 2.1 39.4 1.0 O2 A:OGA601 2.1 52.2 1.0 C2 A:OGA601 2.7 47.1 1.0 C1 A:OGA601 2.8 50.6 1.0 CE1 A:HIS231 2.8 41.2 1.0 CE1 A:HIS307 2.9 39.9 1.0 CG A:ASP233 3.0 37.9 1.0 CD2 A:HIS307 3.1 40.1 1.0 CD2 A:HIS231 3.2 40.9 1.0 OD2 A:ASP233 3.2 37.4 1.0 O2 A:GOL602 3.9 39.8 1.0 O A:HOH703 3.9 53.2 1.0 N1 A:OGA601 4.0 45.4 1.0 O1 A:GOL602 4.0 42.0 1.0 O1 A:OGA601 4.0 51.7 1.0 ND1 A:HIS231 4.0 41.4 1.0 ND1 A:HIS307 4.1 39.6 1.0 CG A:HIS307 4.2 39.2 1.0 CG A:HIS231 4.2 41.5 1.0 NH2 A:ARG322 4.3 48.7 1.0 CB A:ASP233 4.4 37.9 1.0 C4 A:OGA601 4.6 44.4 1.0 CA A:ASP233 4.7 38.2 1.0 N A:ASP233 4.8 37.3 1.0 C2 A:GOL602 4.9 39.9 1.0 C1 A:GOL602 5.0 41.2 1.0

W.S.Aik, M.Demetriades, M.K.K.Hamdan, E.A.L.Bagg, K.K.Yeoh, C.Lejeune, Z.Zhang, M.A.Mcdonough, C.J.Schofield. Structural Basis For Inhibition of the Fat Mass and Obesity Associated Protein (Fto) J.Med.Chem. V. 56 3680 2013.
ISSN: ISSN 0022-2623
PubMed: 23547775
DOI: 10.1021/JM400193D