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Atomistry » Nickel » PDB 4guh-4jz4 » 4jpc | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Nickel » PDB 4guh-4jz4 » 4jpc » |
Nickel in PDB 4jpc: Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) InhibitorsEnzymatic activity of Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
All present enzymatic activity of Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors:
3.4.23.46; Protein crystallography data
The structure of Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors, PDB code: 4jpc
was solved by
G.P.A.Vigers,
D.Smith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Nickel Binding Sites:
The binding sites of Nickel atom in the Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
(pdb code 4jpc). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors, PDB code: 4jpc: Nickel binding site 1 out of 1 in 4jpcGo back to Nickel Binding Sites List in 4jpc
Nickel binding site 1 out
of 1 in the Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors
Mono view Stereo pair view
Reference:
K.W.Hunt,
A.W.Cook,
R.J.Watts,
C.T.Clark,
G.Vigers,
D.Smith,
A.T.Metcalf,
I.W.Gunawardana,
M.Burkard,
A.A.Cox,
M.K.Geck Do,
D.Dutcher,
A.A.Thomas,
S.Rana,
N.C.Kallan,
R.K.Delisle,
J.P.Rizzi,
K.Regal,
D.Sammond,
R.Groneberg,
M.Siu,
H.Purkey,
J.P.Lyssikatos,
A.Marlow,
X.Liu,
T.P.Tang.
Spirocyclic Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors: From Hit to Lowering of Cerebrospinal Fluid (Csf) Amyloid Beta in A Higher Species. J.Med.Chem. V. 56 3379 2013.
Page generated: Wed Oct 9 18:17:04 2024
ISSN: ISSN 0022-2623 PubMed: 23537249 DOI: 10.1021/JM4002154 |
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