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Nickel in PDB 4pzw: Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors
Enzymatic activity of Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors
All present enzymatic activity of Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors:
3.4.23.46;
3.4.23.46;
Protein crystallography data
The structure of Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors, PDB code: 4pzw
was solved by
G.P.A.Vigers,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 29.13 / 1.80 |
| Space group | C 2 2 21 |
| Cell size a, b, c (Å), α, β, γ (°) | 75.170, 103.940, 99.730, 90.00, 90.00, 90.00 |
| R / Rfree (%) | 20.2 / 23.1 |
Other elements in 4pzw:
The structure of Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors also contains other interesting chemical elements:
| Chlorine | (Cl) | 1 atom |
Nickel Binding Sites:
The binding sites of Nickel atom in the Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors
(pdb code 4pzw). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors, PDB code: 4pzw:
In total only one binding site of Nickel was determined in the Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors, PDB code: 4pzw:
Nickel binding site 1 out of 1 in 4pzw
Go back to
Nickel Binding Sites List in 4pzw
Nickel binding site 1 out
of 1 in the Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 1 of Synthesis, Characterization and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors within 5.0Å range:
|
Reference:
M.Volgraf,
L.Chan,
M.P.Huestis,
H.E.Purkey,
M.Burkard,
M.Geck Do,
J.Harris,
K.W.Hunt,
X.Liu,
J.P.Lyssikatos,
S.Rana,
A.A.Thomas,
G.P.Vigers,
M.Siu.
Synthesis, Characterization, and Pk/Pd Studies of A Series of Spirocyclic Pyranochromene BACE1 Inhibitors. Bioorg.Med.Chem.Lett. V. 24 2477 2014.
ISSN: ISSN 0960-894X
PubMed: 24780121
DOI: 10.1016/J.BMCL.2014.04.012
Page generated: Wed Oct 9 18:38:42 2024
ISSN: ISSN 0960-894X
PubMed: 24780121
DOI: 10.1016/J.BMCL.2014.04.012
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