Nickel in PDB 4zxs: Hsv-1 Nuclear Egress Complex

The structure of Hsv-1 Nuclear Egress Complex, PDB code: 4zxs was solved by J.M.Bigalke, E.E.Heldwein, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	47.86 / 2.77
Space group	P 6
Cell size a, b, c (Å), α, β, γ (°)	110.529, 110.529, 155.850, 90.00, 90.00, 120.00
R / Rfree (%)	21.7 / 26.5

The structure of Hsv-1 Nuclear Egress Complex also contains other interesting chemical elements:

Zinc	(Zn)	2 atoms
Chlorine	(Cl)	3 atoms
Sodium	(Na)	2 atoms

The binding sites of Nickel atom in the Hsv-1 Nuclear Egress Complex (pdb code 4zxs). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Hsv-1 Nuclear Egress Complex, PDB code: 4zxs:
Jump to Nickel binding site number: 1; 2;

Nickel binding site 1 out of 2 in the Hsv-1 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Hsv-1 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni201 b:0.6 occ:1.00 NE2 A:HIS57 2.2 69.0 1.0 NE2 A:HIS55 2.3 68.2 1.0 CL A:CL202 2.9 92.1 1.0 O A:HOH311 3.0 64.8 1.0 CE1 A:HIS55 3.2 50.8 1.0 CE1 A:HIS57 3.2 83.5 1.0 CD2 A:HIS57 3.2 65.9 1.0 CD2 A:HIS55 3.3 43.4 1.0 O A:HOH308 3.4 42.3 1.0 O A:HOH312 3.6 29.4 1.0 ND1 A:HIS55 4.3 63.0 1.0 ND1 A:HIS57 4.3 85.1 1.0 CG A:HIS57 4.3 66.9 1.0 CG A:HIS55 4.3 53.8 1.0

Nickel binding site 2 out of 2 in the Hsv-1 Nuclear Egress Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Hsv-1 Nuclear Egress Complex within 5.0Å range: probe atom residue distance (Å) B Occ C:Ni201 b:74.4 occ:1.00 O C:HOH313 2.6 67.1 1.0 NE2 C:HIS57 2.6 89.0 1.0 NE2 C:HIS55 2.6 62.1 1.0 CE1 C:HIS57 2.8 96.5 1.0 CE1 C:HIS55 2.8 64.6 1.0 CL C:CL202 2.8 99.9 1.0 O C:HOH302 3.1 60.8 1.0 NH1 C:ARG32 3.7 0.0 1.0 CD2 C:HIS57 3.9 76.1 1.0 CD2 C:HIS55 4.0 58.6 1.0 ND1 C:HIS57 4.0 93.1 1.0 ND1 C:HIS55 4.1 74.8 1.0 CG C:HIS57 4.6 76.5 1.0 CG C:HIS55 4.7 56.5 1.0 CZ C:ARG32 4.9 1.0 1.0

J.M.Bigalke, E.E.Heldwein. Structural Basis of Membrane Budding By the Nuclear Egress Complex of Herpesviruses. Embo J. V. 34 2921 2015.
ISSN: ESSN 1460-2075
PubMed: 26511020
DOI: 10.15252/EMBJ.201592359