Nickel in PDB 6ec0: Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10)

The structure of Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10), PDB code: 6ec0 was solved by S.A.Eldirany, I.B.Lomakin, C.G.Bunick, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	46.20 / 2.98
Space group	P 31 2 1
Cell size a, b, c (Å), α, β, γ (°)	106.685, 106.685, 70.321, 90.00, 90.00, 120.00
R / Rfree (%)	28.1 / 30

The structure of Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10) also contains other interesting chemical elements:

Cobalt	(Co)	2 atoms
Cadmium	(Cd)	4 atoms

The binding sites of Nickel atom in the Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10) (pdb code 6ec0). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10), PDB code: 6ec0:
Jump to Nickel binding site number: 1; 2;

Nickel binding site 1 out of 2 in the Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10)


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ni303 b:0.6 occ:1.00 OD1 B:ASP233 2.2 0.9 1.0 CG B:ASP233 3.0 0.7 1.0 OD2 B:ASP233 3.3 89.7 1.0 CB B:ASP233 4.1 76.5 1.0 HB3 B:LEU229 4.2 1.0 1.0 HB2 B:ASP233 4.2 91.9 1.0 HA B:ASP233 4.3 0.7 1.0 O B:LEU229 4.3 0.9 1.0 H B:ASP233 4.4 0.2 1.0 CA B:ASP233 4.6 97.3 1.0 HD22 B:LEU229 4.6 0.5 1.0 N B:ASP233 4.7 87.7 1.0 HB2 B:ASP232 4.8 0.9 1.0 HB3 B:ASP233 4.9 91.9 1.0 C B:LEU229 5.0 0.0 1.0

Nickel binding site 2 out of 2 in the Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10)


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of the Wild-Type Heterocomplex Between Coil 1B Domains of Human Intermediate Filament Proteins Keratin 1 (KRT1) and Keratin 10 (KRT10) within 5.0Å range: probe atom residue distance (Å) B Occ B:Ni304 b:1.0 occ:1.00 OE2 B:GLU279 3.3 0.4 1.0 OE1 B:GLU279 3.8 0.1 1.0 HE22 A:GLN309 3.9 0.7 1.0 CD B:GLU279 3.9 0.6 1.0 O B:HOH410 4.0 0.5 1.0 NE2 A:GLN309 4.7 0.3 1.0 OE1 A:GLN309 4.9 0.1 1.0

S.A.Eldirany, M.Ho, A.J.Hinbest, I.B.Lomakin, C.G.Bunick. Human Keratin 1/10-1B Tetramer Structures Reveal A Knob-Pocket Mechanism in Intermediate Filament Assembly. Embo J. V. 38 2019.
ISSN: ESSN 1460-2075
PubMed: 31036554
DOI: 10.15252/EMBJ.2018100741