Nickel in PDB 7nx4: Crystal Structure of the Tg and Egf-Like Domains of Alk

All present enzymatic activity of Crystal Structure of the Tg and Egf-Like Domains of Alk:
2.7.10.1;

The structure of Crystal Structure of the Tg and Egf-Like Domains of Alk, PDB code: 7nx4 was solved by S.De Munck, S.N.Savvides, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	60.05 / 3.00
Space group	I 41
Cell size a, b, c (Å), α, β, γ (°)	84.93, 84.93, 148.666, 90, 90, 90
R / Rfree (%)	21.9 / 24.7

The structure of Crystal Structure of the Tg and Egf-Like Domains of Alk also contains other interesting chemical elements:

Zinc

(Zn)

1 atom

The binding sites of Nickel atom in the Crystal Structure of the Tg and Egf-Like Domains of Alk (pdb code 7nx4). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Crystal Structure of the Tg and Egf-Like Domains of Alk, PDB code: 7nx4:
Jump to Nickel binding site number: 1; 2;

Nickel binding site 1 out of 2 in the Crystal Structure of the Tg and Egf-Like Domains of Alk


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of the Tg and Egf-Like Domains of Alk within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni1106 b:119.8 occ:1.00 OE1 A:GLU780 3.1 89.1 1.0 OE2 A:GLU780 3.5 109.7 1.0 OE2 A:GLU916 3.5 85.8 1.0 CD A:GLU780 3.6 108.0 1.0 CB A:GLU916 3.9 98.4 1.0 O A:GLU916 4.1 110.5 1.0 CD A:GLU916 4.4 90.9 1.0 CG A:GLU916 4.8 99.9 1.0 C A:GLU916 4.8 92.1 1.0 CA A:GLU916 5.0 77.9 1.0

Nickel binding site 2 out of 2 in the Crystal Structure of the Tg and Egf-Like Domains of Alk


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of the Tg and Egf-Like Domains of Alk within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni1107 b:267.4 occ:1.00 OD2 A:ASP954 2.1 232.6 1.0 NZ A:LYS971 2.7 122.5 1.0 OE2 A:GLU859 2.7 141.0 1.0 CG A:ASP954 3.0 172.7 1.0 OD1 A:ASP954 3.4 192.0 1.0 O A:HIS857 3.6 162.4 1.0 CD A:GLU859 3.8 137.2 1.0 CE A:LYS971 3.8 123.2 1.0 CD A:LYS971 3.9 147.4 1.0 OG A:SER754 4.0 119.4 1.0 OE1 A:GLU859 4.0 137.5 1.0 CB A:HIS857 4.0 180.7 1.0 CB A:ASP954 4.2 120.9 1.0 C A:HIS857 4.3 165.8 1.0 N A:HIS857 4.4 170.7 1.0 CA A:HIS857 4.5 175.8 1.0 O A:PRO858 4.8 167.4 1.0

S.De Munck, M.Provost, M.Kurikawa, I.Omori, J.Mukohyama, J.Felix, Y.Bloch, O.Abdel-Wahab, J.F.Bazan, A.Yoshimi, S.N.Savvides. Structural Basis of Cytokine-Mediated Activation of Alk Family Receptors. Nature 2021.
ISSN: ESSN 1476-4687
PubMed: 34646012
DOI: 10.1038/S41586-021-03959-5