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Nickel in PDB 8cg9: Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor

Enzymatic activity of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor

All present enzymatic activity of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor:
3.5.2.6;

Protein crystallography data

The structure of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor, PDB code: 8cg9 was solved by J.A.Newman, Y.Yosaatmadja, H.T.Baddock, M.Bielinski, F.Von Delft, C.Bountra, P.J.Mchugh, C.J.Schofield, O.Gileadi, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 51.08 / 1.68
Space group P 21 21 21
Cell size a, b, c (Å), α, β, γ (°) 51.522, 57.148, 113.903, 90, 90, 90
R / Rfree (%) 22.3 / 23.1

Other elements in 8cg9:

The structure of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor also contains other interesting chemical elements:

Zinc (Zn) 1 atom

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor (pdb code 8cg9). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor, PDB code: 8cg9:

Nickel binding site 1 out of 1 in 8cg9

Go back to Nickel Binding Sites List in 8cg9
Nickel binding site 1 out of 1 in the Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1101

b:21.1
occ:1.00
O23 A:R3Z1103 2.1 23.3 1.0
ND1 A:HIS734 2.1 22.0 1.0
NE2 A:HIS793 2.1 20.7 1.0
NE2 A:HIS732 2.2 23.7 1.0
O19 A:R3Z1103 2.2 27.3 1.0
OD2 A:ASP815 2.3 21.4 1.0
N20 A:R3Z1103 2.8 29.8 1.0
C18 A:R3Z1103 2.8 30.5 1.0
CE1 A:HIS734 3.0 23.9 1.0
CD2 A:HIS732 3.1 19.2 1.0
CE1 A:HIS793 3.1 18.4 1.0
CD2 A:HIS793 3.1 18.3 1.0
CG A:HIS734 3.2 25.5 1.0
CE1 A:HIS732 3.2 21.2 1.0
ZN A:ZN1104 3.3 28.8 1.0
CG A:ASP815 3.3 24.8 1.0
CB A:HIS734 3.5 24.1 1.0
CB A:ASP815 3.6 20.1 1.0
O23 A:XOB1102 3.8 35.5 1.0
NE2 A:HIS737 3.9 30.0 1.0
C21 A:R3Z1103 4.0 33.9 1.0
C17 A:R3Z1103 4.1 34.4 1.0
CD2 A:HIS737 4.2 30.3 1.0
NE2 A:HIS734 4.2 24.3 1.0
ND1 A:HIS793 4.2 18.4 1.0
CG A:HIS732 4.2 20.7 1.0
CG A:HIS793 4.2 17.8 1.0
CD2 A:HIS734 4.3 25.6 1.0
ND1 A:HIS732 4.3 23.3 1.0
OD1 A:ASP815 4.5 24.8 1.0
O22 A:R3Z1103 4.6 28.6 1.0
CE1 A:HIS994 4.6 22.6 1.0
NE2 A:HIS994 4.6 22.9 1.0
CE1 A:HIS737 4.8 29.7 1.0
N20 A:XOB1102 4.9 33.5 1.0

Reference:

J.A.Newman, Y.Yosaatmadja, H.T.Baddock, M.Bielinski, F.Von Delft, C.Bountra, P.J.Mchugh, C.J.Schofield, O.Gileadi. Crystal Structure of Human Dna Cross-Link Repair 1A in Complex with A Cyclic N-Hydroxyurea Inhibitor To Be Published.
Page generated: Thu Oct 10 09:38:15 2024

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