Nickel in PDB 8qhg: Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid)

The structure of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid), PDB code: 8qhg was solved by C.Baroni, M.Ferraroni, F.Carta, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	78.67 / 1.91
Space group	I 4 3 2
Cell size a, b, c (Å), α, β, γ (°)	157.33, 157.33, 157.33, 90, 90, 90
R / Rfree (%)	19.2 / 22

The structure of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) also contains other interesting chemical elements:

Chlorine	(Cl)	2 atoms
Zinc	(Zn)	1 atom

The binding sites of Nickel atom in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) (pdb code 8qhg). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid), PDB code: 8qhg:

Nickel binding site 1 out of 1 in the Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid)


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4- Dichloro 5-Sulfamoyl Benzoic Acid) within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni303 b:39.0 occ:1.00 NE2 A:HIS-5 1.9 27.4 1.0 CE1 A:HIS-5 2.7 35.6 1.0 CD2 A:HIS-5 3.1 37.9 1.0 ND1 A:HIS-5 3.9 33.5 1.0 CG A:HIS-5 4.1 31.3 1.0

C.Baroni, M.Ferraroni, F.Carta. Human Carbonic Anhydrase IX Mimic in Complex with Lasamide (2,4-Dichloro 5-Sulfamoyl Benzoic Acid) To Be Published.