Nickel in PDB 1kic: Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine

Enzymatic activity of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine

All present enzymatic activity of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine:
3.2.2.1;

Protein crystallography data

The structure of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine, PDB code: 1kic was solved by W.Versees, K.Decanniere, E.Van Holsbeke, N.Devroede, J.Steyaert, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	50.00 / 1.60
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	54.350, 74.620, 73.020, 90.00, 98.31, 90.00
*R / R_free (%)*	17.6 / 19.4

Other elements in 1kic:

The structure of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

Nickel Binding Sites:

The binding sites of Nickel atom in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine (pdb code 1kic). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine, PDB code: 1kic:

Nickel binding site 1 out of 1 in 1kic

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Nickel Binding Sites List in 1kic

Nickel binding site 1 out of 1 in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine

Mono view

Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with Inosine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ni701 b:11.1 occ:1.00	OE2	A:GLU113	1.9	13.0	1.0
	OE2	A:GLU44	2.0	14.4	1.0
	N7	A:NOS804	2.1	14.1	0.7
	CD	A:GLU113	2.8	12.3	1.0
	CD	A:GLU44	2.8	13.2	1.0
	C8	A:NOS804	3.0	18.7	0.7
	OE1	A:GLU113	3.1	13.3	1.0
	OE1	A:GLU44	3.1	13.4	1.0
	C5	A:NOS804	3.2	17.2	0.7
	O6	A:NOS804	3.7	15.2	0.7
	C6	A:NOS804	3.8	15.0	0.7
	O	A:HOH1036	3.9	30.7	1.0
	CG	A:GLU113	4.1	12.9	1.0
	N9	A:NOS804	4.1	19.2	0.7
	CG	A:GLU44	4.2	12.4	1.0
	C4	A:NOS804	4.3	18.1	0.7
	CE	A:LYS109	4.4	22.5	1.0
	CE	A:LYS70	4.6	18.3	1.0
	CE2	A:PHE47	4.8	12.4	1.0
	CD2	A:PHE47	5.0	11.9	1.0

Reference:

W.Versees, K.Decanniere, E.Van Holsbeke, N.Devroede, J.Steyaert. Enzyme-Substrate Interactions in the Purine-Specific Nucleoside Hydrolase From Trypanosoma Vivax. J.Biol.Chem. V. 277 15938 2002.
ISSN: ISSN 0021-9258
PubMed: 11854281
DOI: 10.1074/JBC.M111735200

Page generated: Wed Oct 9 15:01:42 2024

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