Nickel in PDB 1kie: Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine

Enzymatic activity of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine

All present enzymatic activity of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine:
3.2.2.1;

Protein crystallography data

The structure of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine, PDB code: 1kie was solved by W.Versees, K.Decanniere, E.Van Holsbeke, N.Devroede, J.Steyaert, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

*Resolution Low / High (Å)*	20.00 / 2.00
*Space group*	P 1 2₁ 1
*Cell size a, b, c (Å), α, β, γ (°)*	53.270, 72.960, 71.530, 90.00, 98.18, 90.00
*R / R_free (%)*	15.6 / 21.5

Other elements in 1kie:

The structure of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine also contains other interesting chemical elements:

Calcium

(Ca)

2 atoms

Nickel Binding Sites:

The binding sites of Nickel atom in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine (pdb code 1kie). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine, PDB code: 1kie:

Nickel binding site 1 out of 1 in 1kie

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Nickel Binding Sites List in 1kie

Nickel binding site 1 out of 1 in the Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine

Mono view

Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Inosine-Adenosine-Guanosine Preferring Nucleoside Hydrolase From Trypanosoma Vivax: ASP10ALA Mutant in Complex with 3- Deaza-Adenosine within 5.0Å range:

probe	atom	residue	distance (Å)	B	Occ
A:Ni701 b:20.0 occ:1.00	OE2	A:GLU113	1.9	22.0	1.0
	OE2	A:GLU44	2.0	18.7	1.0
	O	A:HOH957	2.1	17.3	1.0
	CD	A:GLU113	2.7	19.0	1.0
	CD	A:GLU44	2.8	18.3	1.0
	OE1	A:GLU113	3.0	19.1	1.0
	OE1	A:GLU44	3.0	17.0	1.0
	O	A:HOH813	3.7	17.9	1.0
	O	A:HOH962	3.8	24.9	1.0
	CG	A:GLU113	4.1	19.7	1.0
	CG	A:GLU44	4.2	17.6	1.0
	CE	A:LYS70	4.3	20.3	1.0
	CE	A:LYS109	4.4	21.2	1.0
	CE2	A:PHE47	4.6	18.6	1.0
	O	A:HOH814	4.8	18.5	1.0
	CD2	A:PHE47	4.8	20.6	1.0
	NZ	A:LYS109	5.0	20.5	1.0
	NZ	A:LYS70	5.0	24.9	1.0

Reference:

W.Versees, K.Decanniere, E.Van Holsbeke, N.Devroede, J.Steyaert. Enzyme-Substrate Interactions in the Purine-Specific Nucleoside Hydrolase From Trypanosoma Vivax. J.Biol.Chem. V. 277 15938 2002.
ISSN: ISSN 0021-9258
PubMed: 11854281
DOI: 10.1074/JBC.M111735200

Page generated: Wed Oct 9 15:01:43 2024

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