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Nickel in PDB 2c7v: Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate
Enzymatic activity of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate
All present enzymatic activity of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate:
1.5.1.33;
1.5.1.33;
Protein crystallography data
The structure of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate, PDB code: 2c7v
was solved by
A.Dawson,
F.Gibellini,
N.Sienkiewicz,
P.K.Fyfe,
K.Mcluskey,
A.H.Fairlamb,
W.N.Hunter,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 74.54 / 2.20 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 74.655, 90.244, 82.841, 90.00, 115.76, 90.00 |
| R / Rfree (%) | 15.3 / 22.3 |
Other elements in 2c7v:
The structure of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate also contains other interesting chemical elements:
| Arsenic | (As) | 8 atoms |
Nickel Binding Sites:
The binding sites of Nickel atom in the Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate
(pdb code 2c7v). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate, PDB code: 2c7v:
Jump to Nickel binding site number: 1; 2;
In total 2 binding sites of Nickel where determined in the Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate, PDB code: 2c7v:
Jump to Nickel binding site number: 1; 2;
Nickel binding site 1 out of 2 in 2c7v
Go back to
Nickel Binding Sites List in 2c7v
Nickel binding site 1 out
of 2 in the Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 1 of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate within 5.0Å range:
|
Nickel binding site 2 out of 2 in 2c7v
Go back to
Nickel Binding Sites List in 2c7v
Nickel binding site 2 out
of 2 in the Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 2 of Structure of Trypanosoma Brucei Pteridine Reductase (PTR1) in Ternary Complex with Cofactor and the Antifolate Methotrexate within 5.0Å range:
|
Reference:
A.Dawson,
F.Gibellini,
N.Sienkiewicz,
L.B.Tulloch,
P.K.Fyfe,
K.Mcluskey,
A.H.Fairlamb,
W.N.Hunter.
Structure and Reactivity of Trypanosoma Brucei Pteridine Reductase: Inhibition By the Archetypal Antifolate Methotrexate Mol.Microbiol. V. 61 1457 2006.
ISSN: ISSN 0950-382X
PubMed: 16968221
DOI: 10.1111/J.1365-2958.2006.05332.X
Page generated: Mon Aug 18 18:09:12 2025
ISSN: ISSN 0950-382X
PubMed: 16968221
DOI: 10.1111/J.1365-2958.2006.05332.X
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