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Nickel in PDB 2cfv: Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J

Enzymatic activity of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J

All present enzymatic activity of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J:
3.1.3.48;

Protein crystallography data

The structure of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J, PDB code: 2cfv was solved by J.E.Debreczeni, A.J.Barr, J.Eswaran, E.Ugochukwu, M.Sundstrom, J.Weigelt, C.Arrowsmith, A.Edwards, S.Knapp, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 63.25 / 2.50
Space group H 3
Cell size a, b, c (Å), α, β, γ (°) 86.060, 86.060, 119.540, 90.00, 90.00, 120.00
R / Rfree (%) 20.1 / 25

Other elements in 2cfv:

The structure of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J also contains other interesting chemical elements:

Chlorine (Cl) 1 atom

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J (pdb code 2cfv). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 4 binding sites of Nickel where determined in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J, PDB code: 2cfv:
Jump to Nickel binding site number: 1; 2; 3; 4;

Nickel binding site 1 out of 4 in 2cfv

Go back to Nickel Binding Sites List in 2cfv
Nickel binding site 1 out of 4 in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni2302

b:15.6
occ:0.33
 NE2 A:HIS-18 2.0 26.8 1.0
NE2 A:HIS-16 2.2 23.6 1.0
CE1 A:HIS-18 2.9 28.1 1.0
CD2 A:HIS-18 3.0 27.8 1.0
CE1 A:HIS-16 3.0 25.6 1.0
CD2 A:HIS-16 3.2 24.4 1.0
ND1 A:HIS-18 4.0 26.0 1.0
CG A:HIS-18 4.1 25.1 1.0
ND1 A:HIS-16 4.2 24.6 1.0
CG A:HIS-16 4.3 25.0 1.0

Nickel binding site 2 out of 4 in 2cfv

Go back to Nickel Binding Sites List in 2cfv
Nickel binding site 2 out of 4 in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni2303

b:28.0
occ:1.00
 NZ A:LYS1106 1.8 42.4 1.0
O A:HOH2019 2.0 16.0 1.0
NE2 A:HIS1277 2.2 31.2 1.0
CL A:CL2304 2.4 53.8 1.0
CE1 A:HIS1277 3.1 31.7 1.0
CE A:LYS1106 3.1 43.2 1.0
CD2 A:HIS1277 3.2 31.1 1.0
CD A:LYS1106 4.2 42.5 1.0
ND1 A:HIS1277 4.2 34.2 1.0
CG A:HIS1277 4.3 33.0 1.0

Nickel binding site 3 out of 4 in 2cfv

Go back to Nickel Binding Sites List in 2cfv
Nickel binding site 3 out of 4 in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni2305

b:42.6
occ:0.33
 O A:HOH2005 2.6 37.4 0.3
O A:HOH2002 2.9 25.4 1.0
O A:HOH2001 5.0 38.1 1.0

Nickel binding site 4 out of 4 in 2cfv

Go back to Nickel Binding Sites List in 2cfv
Nickel binding site 4 out of 4 in the Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 4 of Crystal Structure of Human Protein Tyrosine Phosphatase Receptor Type J within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni2306

b:39.1
occ:1.00
 O A:HOH2004 2.4 29.8 1.0
O A:HOH2003 2.8 23.9 1.0
O A:HOH2002 3.1 25.4 1.0
N A:HIS-19 3.5 28.4 1.0
CA A:HIS-19 4.8 28.4 1.0

Reference:

A.J.Barr, E.Ugochukwu, W.H.Lee, O.N.F.King, P.Filippakopoulos, I.Alfano, P.Savitsky, N.A.Burgess-Brown, S.Muller, S.Knapp. Large-Scale Structural Analysis of the Classical Human Protein Tyrosine Phosphatome. Cell(Cambridge,Mass.) V. 136 352 2009.
ISSN: ISSN 0092-8674
PubMed: 19167335
DOI: 10.1016/J.CELL.2008.11.038
Page generated: Wed Oct 9 16:41:16 2024

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