Nickel in PDB 4j7t: Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis

All present enzymatic activity of Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis:
4.4.1.20;

The structure of Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis, PDB code: 4j7t was solved by D.Niegowski, A.Rinaldo-Matthis, J.Z.Haeggstrom, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	37.65 / 3.20
Space group	F 2 3
Cell size a, b, c (Å), α, β, γ (°)	168.392, 168.392, 168.392, 90.00, 90.00, 90.00
R / Rfree (%)	22 / 24.6

The binding sites of Nickel atom in the Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis (pdb code 4j7t). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis, PDB code: 4j7t:

Nickel binding site 1 out of 1 in the Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Human LTC4 Synthase in Complex with Product Analogs - Implications For Enzyme Catalysis within 5.0Å range: probe atom residue distance (Å) B Occ A:Ni201 b:0.2 occ:0.33 NE2 A:HIS1 2.1 0.1 1.0 CD2 A:HIS1 2.9 98.4 1.0 NE2 A:HIS-1 3.1 0.7 1.0 CE1 A:HIS1 3.3 0.6 1.0 CE1 A:HIS-1 4.0 0.9 1.0 CD2 A:HIS-1 4.0 0.3 1.0 CG A:HIS1 4.1 93.1 1.0 ND1 A:HIS1 4.2 0.2 1.0

D.Niegowski, T.Kleinschmidt, U.Olsson, S.Ahmad, A.Rinaldo-Matthis, J.Z.Haeggstrom. Crystal Structures of Leukotriene C4 Synthase in Complex with Product Analogs: Implications For the Enzyme Mechanism. J.Biol.Chem. V. 289 5199 2014.
ISSN: ISSN 0021-9258
PubMed: 24366866
DOI: 10.1074/JBC.M113.534628