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Atomistry » Nickel » PDB 4lto-4ofl » 4n00 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Atomistry » Nickel » PDB 4lto-4ofl » 4n00 » |
Nickel in PDB 4n00: Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the CnsEnzymatic activity of Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns
All present enzymatic activity of Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns:
3.4.23.46; Protein crystallography data
The structure of Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns, PDB code: 4n00
was solved by
G.P.A Vigers,
D.Smith,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
Other elements in 4n00:
The structure of Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns also contains other interesting chemical elements:
Nickel Binding Sites:
The binding sites of Nickel atom in the Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns
(pdb code 4n00). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns, PDB code: 4n00: Nickel binding site 1 out of 1 in 4n00Go back to![]() ![]()
Nickel binding site 1 out
of 1 in the Discovery of 7-Thp Chromans: BACE1 Inhibitors That Reduce A-Beta in the Cns
![]() Mono view ![]() Stereo pair view
Reference:
A.A.Thomas,
K.W.Hunt,
M.Volgraf,
R.J.Watts,
X.Liu,
G.Vigers,
D.Smith,
D.Sammond,
T.P.Tang,
S.P.Rhodes,
A.T.Metcalf,
K.D.Brown,
J.N.Otten,
M.Burkard,
A.A.Cox,
M.K.Do,
D.Dutcher,
S.Rana,
R.K.Delisle,
K.Regal,
A.D.Wright,
R.Groneberg,
K.Scearce-Levie,
M.Siu,
H.E.Purkey,
J.P.Lyssikatos,
I.W.Gunawardana.
Discovery of 7-Tetrahydropyran-2-Yl Chromans: Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1 (BACE1) Inhibitors That Reduce Amyloid Beta-Protein (A Beta ) in the Central Nervous System. J.Med.Chem. V. 57 878 2014.
Page generated: Wed Oct 9 18:33:35 2024
ISSN: ISSN 0022-2623 PubMed: 24397738 DOI: 10.1021/JM401635N |
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