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Nickel in PDB 6mvd: Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator
Enzymatic activity of Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator
All present enzymatic activity of Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator:
2.3.1.43;
2.3.1.43;
Protein crystallography data
The structure of Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator, PDB code: 6mvd
was solved by
K.A.Manthei,
L.Chang,
J.J.G.Tesmer,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | 28.80 / 3.10 |
| Space group | C 1 2 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 134.697, 106.377, 117.823, 90.00, 125.45, 90.00 |
| R / Rfree (%) | 19.3 / 23.9 |
Other elements in 6mvd:
The structure of Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator also contains other interesting chemical elements:
| Fluorine | (F) | 12 atoms |
Nickel Binding Sites:
The binding sites of Nickel atom in the Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator
(pdb code 6mvd). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total only one binding site of Nickel was determined in the Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator, PDB code: 6mvd:
In total only one binding site of Nickel was determined in the Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator, PDB code: 6mvd:
Nickel binding site 1 out of 1 in 6mvd
Go back to
Nickel Binding Sites List in 6mvd
Nickel binding site 1 out
of 1 in the Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 1 of Crystal Structure of Lecithin:Cholesterol Acyltransferase (Lcat) in Complex with Isopropyl Dodec-11-Enylfluorophosphonate (Idfp) and A Small Molecule Activator within 5.0Å range:
|
Reference:
K.A.Manthei,
S.M.Yang,
B.Baljinnyam,
L.Chang,
A.Glukhova,
W.Yuan,
L.A.Freeman,
D.J.Maloney,
A.Schwendeman,
A.T.Remaley,
A.Jadhav,
J.J.Tesmer.
Molecular Basis For Activation of Lecithin:Cholesterol Acyltransferase By A Compound That Increases Hdl Cholesterol. Elife V. 7 2018.
ISSN: ESSN 2050-084X
PubMed: 30479275
DOI: 10.7554/ELIFE.41604
Page generated: Thu Oct 10 08:43:12 2024
ISSN: ESSN 2050-084X
PubMed: 30479275
DOI: 10.7554/ELIFE.41604
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