Atomistry » Nickel » PDB 8cjb-8ka3 » 8fvf
Atomistry »
  Nickel »
    PDB 8cjb-8ka3 »
      8fvf »

Nickel in PDB 8fvf: Bromodomain of EP300 Liganded with Ccs-1477

Enzymatic activity of Bromodomain of EP300 Liganded with Ccs-1477

All present enzymatic activity of Bromodomain of EP300 Liganded with Ccs-1477:
2.3.1.48;

Protein crystallography data

The structure of Bromodomain of EP300 Liganded with Ccs-1477, PDB code: 8fvf was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 19.74 / 2.10
Space group P 4 21 2
Cell size a, b, c (Å), α, β, γ (°) 103.15, 103.15, 59.22, 90, 90, 90
R / Rfree (%) 18.1 / 23.9

Other elements in 8fvf:

The structure of Bromodomain of EP300 Liganded with Ccs-1477 also contains other interesting chemical elements:

Fluorine (F) 4 atoms

Nickel Binding Sites:

The binding sites of Nickel atom in the Bromodomain of EP300 Liganded with Ccs-1477 (pdb code 8fvf). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 9 binding sites of Nickel where determined in the Bromodomain of EP300 Liganded with Ccs-1477, PDB code: 8fvf:
Jump to Nickel binding site number: 1; 2; 3; 4; 5; 6; 7; 8; 9;

Nickel binding site 1 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 1 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1203

b:20.1
occ:1.00
O A:HOH1363 1.9 20.9 1.0
OD2 A:ASP1119 2.2 24.9 1.0
O A:HOH1377 2.3 23.8 1.0
O A:HOH1392 2.4 27.0 1.0
OD1 A:ASP1119 2.7 18.0 1.0
O A:HOH1342 2.7 24.4 1.0
CG A:ASP1119 2.7 15.5 1.0
O A:HOH1378 3.7 27.3 1.0
CB A:ASP1119 4.2 16.8 1.0
O A:HOH1396 4.4 31.6 1.0
O A:ASP1119 4.4 17.3 1.0
C A:ASP1119 4.8 14.7 1.0
CA A:ASP1119 4.9 18.6 1.0

Nickel binding site 2 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 2 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1204

b:30.6
occ:1.00
O B:HOH1303 1.9 35.9 1.0
O A:HOH1325 2.1 15.8 1.0
OE2 B:GLU1152 2.4 30.3 1.0
OE1 A:GLU1152 2.5 26.5 1.0
OE2 A:GLU1152 2.6 32.1 1.0
O A:HOH1380 2.7 31.4 1.0
CD A:GLU1152 2.9 28.7 1.0
OE1 B:GLU1152 2.9 26.4 1.0
CD B:GLU1152 3.0 28.3 1.0
O B:HOH1328 4.0 39.2 1.0
O A:HOH1304 4.3 30.0 1.0
CG A:GLU1152 4.4 27.7 1.0
CG B:GLU1152 4.5 24.1 1.0
O A:HOH1347 4.5 27.8 1.0
O A:HOH1338 4.5 29.1 1.0
O B:HOH1323 4.7 30.2 1.0
O B:HOH1352 4.9 27.3 1.0
O B:HOH1387 5.0 32.3 1.0

Nickel binding site 3 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 3 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1205

b:26.1
occ:1.00
OE2 B:GLU1063 2.0 45.1 1.0
O B:HOH1320 2.1 33.8 1.0
O A:HOH1381 2.3 20.8 1.0
OE1 A:GLU1063 2.4 26.5 1.0
OE2 A:GLU1063 2.5 26.6 1.0
CD A:GLU1063 2.8 27.1 1.0
CD B:GLU1063 2.8 41.4 1.0
OE1 B:GLU1063 3.0 41.5 1.0
O B:HOH1381 3.6 33.5 1.0
O A:HOH1402 3.6 38.2 1.0
O A:HOH1387 4.0 31.4 1.0
CG B:GLU1063 4.2 32.0 1.0
CG A:GLU1063 4.3 23.1 1.0
O A:HOH1316 4.3 24.1 1.0
O A:HOH1373 4.4 37.2 1.0
CG A:PRO1060 4.9 29.9 1.0
CB B:GLU1063 5.0 19.1 1.0

Nickel binding site 4 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 4 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 4 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1206

b:58.0
occ:1.00
OE1 A:GLU1071 2.6 25.4 1.0
O A:HOH1370 2.9 37.5 1.0
OE2 A:GLU1071 3.0 30.7 1.0
CD A:GLU1071 3.1 27.3 1.0
O A:ASP1069 3.4 31.3 1.0
OE1 A:GLN1068 3.7 34.1 1.0
N A:ASP1069 4.0 26.3 1.0
C A:ASP1069 4.1 32.3 1.0
CA A:GLN1068 4.5 23.6 1.0
CG A:GLU1071 4.6 26.5 1.0
C A:GLN1068 4.6 23.9 1.0
CB A:GLN1068 4.6 25.1 1.0
CD A:GLN1068 4.6 29.3 1.0
CD A:PRO1070 4.7 25.9 1.0
NZ A:LYS1144 4.7 38.2 1.0
CA A:ASP1069 4.7 28.4 1.0
N A:PRO1070 4.7 31.2 1.0
CE A:LYS1144 4.9 37.2 1.0

Nickel binding site 5 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 5 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 5 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1207

b:47.2
occ:1.00
O A:HOH1397 2.4 44.3 1.0
NE2 A:GLN1112 2.4 32.6 1.0
O A:HOH1384 2.8 40.3 1.0
CD A:GLN1112 3.7 32.4 1.0
O A:HOH1311 4.3 29.6 1.0
OE1 A:GLN1112 4.5 36.0 1.0
CG A:GLN1112 4.7 29.1 1.0
CB A:GLN1112 4.8 27.5 1.0

Nickel binding site 6 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 6 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 6 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni1208

b:75.3
occ:1.00
OD2 A:ASP1154 2.4 43.9 1.0
OD1 A:ASP1154 2.7 41.0 1.0
OE1 A:GLU1150 2.7 51.6 1.0
CG A:ASP1154 2.9 43.9 1.0
CD A:GLU1150 3.4 56.6 1.0
OE2 A:GLU1150 3.5 53.6 1.0
CB A:ASP1154 4.4 33.6 1.0
O A:HOH1388 4.5 37.5 1.0
CG A:GLU1150 4.7 41.8 1.0
CB A:GLU1150 4.9 29.8 1.0

Nickel binding site 7 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 7 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 7 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni1205

b:27.0
occ:1.00
O B:HOH1370 2.1 33.2 1.0
O B:HOH1301 2.2 30.9 1.0
O B:HOH1379 2.4 39.2 1.0
O B:HOH1359 2.5 25.7 1.0
OE1 B:GLU1071 2.6 20.9 1.0
OE2 B:GLU1071 2.7 32.8 1.0
O B:HOH1394 2.7 32.5 1.0
CD B:GLU1071 3.0 24.8 1.0
NZ B:LYS1144 3.8 35.3 1.0
NE2 B:GLN1068 3.8 20.0 1.0
O B:ASP1069 3.9 26.4 1.0
N B:ASP1069 4.2 24.4 1.0
C B:ASP1069 4.4 25.4 1.0
CG B:GLU1071 4.4 22.1 1.0
CA B:GLN1068 4.6 21.9 1.0
CB B:GLN1068 4.6 24.4 1.0
O A:HOH1395 4.7 35.6 1.0
C B:GLN1068 4.8 23.8 1.0
O B:HOH1306 4.9 34.4 1.0
CD B:PRO1070 4.9 22.0 1.0
CD B:GLN1068 4.9 32.9 1.0
N B:PRO1070 5.0 19.8 1.0

Nickel binding site 8 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 8 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 8 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni1206

b:57.3
occ:1.00
OE2 B:GLU1113 2.1 48.4 1.0
CD B:GLU1113 2.8 37.6 1.0
OE1 B:GLU1113 2.9 34.8 1.0
CG B:GLU1113 4.2 28.4 1.0

Nickel binding site 9 out of 9 in 8fvf

Go back to Nickel Binding Sites List in 8fvf
Nickel binding site 9 out of 9 in the Bromodomain of EP300 Liganded with Ccs-1477


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 9 of Bromodomain of EP300 Liganded with Ccs-1477 within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni1207

b:65.7
occ:1.00
OE1 B:GLU1150 2.5 33.8 1.0
CD B:GLU1150 3.6 36.8 1.0
O B:HOH1324 4.2 31.9 1.0
OE2 B:GLU1150 4.2 35.8 1.0
O B:HOH1373 4.3 29.9 1.0
CG B:GLU1150 4.7 32.7 1.0
CG B:GLU1147 4.9 31.5 1.0
O B:HOH1388 5.0 35.4 1.0

Reference:

E.Schonbrunn, M.Bikowitz. Group 3 Medulloblastoma Transcriptional Networks Are Sensitive to EP300/Cbp Bromodomain Inhibition To Be Published.
Page generated: Thu Oct 10 09:41:57 2024

Last articles

Fe in 2YXO
Fe in 2YRS
Fe in 2YXC
Fe in 2YNM
Fe in 2YVJ
Fe in 2YP1
Fe in 2YU2
Fe in 2YU1
Fe in 2YQB
Fe in 2YOO
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy