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Nickel in PDB 1e0o: Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex

Protein crystallography data

The structure of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex, PDB code: 1e0o was solved by L.Pellegrini, D.F.Burke, F.Von Delft, B.Mulloy, T.L.Blundell, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.20 / 2.80
Space group P 62
Cell size a, b, c (Å), α, β, γ (°) 195.900, 195.900, 68.860, 90.00, 90.00, 120.00
R / Rfree (%) 27.4 / 30.9

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex (pdb code 1e0o). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 5 binding sites of Nickel where determined in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex, PDB code: 1e0o:
Jump to Nickel binding site number: 1; 2; 3; 4; 5;

Nickel binding site 1 out of 5 in 1e0o

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Nickel binding site 1 out of 5 in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni201

b:42.6
occ:1.00
O A:HOH307 2.0 13.7 1.0
NE2 A:HIS93 2.1 57.9 1.0
NE2 B:HIS254 2.4 45.3 1.0
CE1 A:HIS93 2.9 61.2 1.0
CD2 A:HIS93 3.3 53.8 1.0
CE1 B:HIS254 3.3 41.9 1.0
OG B:SER252 3.4 25.7 1.0
CD2 B:HIS254 3.5 45.3 1.0
OD2 B:ASP283 3.9 0.3 1.0
ND1 A:HIS93 4.1 59.2 1.0
OD1 B:ASP283 4.1 1.0 1.0
O A:GLU91 4.3 58.0 1.0
CG A:HIS93 4.3 47.9 1.0
CG B:ASP283 4.4 0.4 1.0
ND1 B:HIS254 4.5 39.4 1.0
CG B:HIS254 4.6 37.9 1.0
CB B:SER252 4.8 39.7 1.0

Nickel binding site 2 out of 5 in 1e0o

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Nickel binding site 2 out of 5 in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni401

b:74.6
occ:1.00
OD1 B:ASP247 2.4 71.1 1.0
NE2 B:HIS245 2.4 75.8 1.0
OD2 B:ASP247 3.0 51.7 1.0
CG B:ASP247 3.1 57.4 1.0
CE1 B:HIS245 3.3 77.2 1.0
CD2 B:HIS245 3.5 74.7 1.0
ND1 B:HIS245 4.4 76.5 1.0
CB B:ASP247 4.5 44.2 1.0
CG B:HIS245 4.6 69.8 1.0

Nickel binding site 3 out of 5 in 1e0o

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Nickel binding site 3 out of 5 in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 3 of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni402

b:50.2
occ:1.00
O B:HOH512 2.0 57.3 1.0
NE2 B:HIS287 2.1 36.4 1.0
CE1 B:HIS287 3.0 44.8 1.0
CD2 B:HIS287 3.1 40.6 1.0
ND1 B:HIS287 4.1 43.0 1.0
CG B:HIS287 4.2 44.1 1.0
OG B:SER347 5.0 50.5 1.0

Nickel binding site 4 out of 5 in 1e0o

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Nickel binding site 4 out of 5 in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 4 of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
C:Ni203

b:26.0
occ:1.00
O D:HOH515 2.1 18.2 1.0
O D:HOH507 2.2 28.8 1.0
NE2 D:HIS254 2.3 33.0 1.0
NE2 C:HIS93 2.4 58.8 1.0
CE1 C:HIS93 3.2 57.6 1.0
CE1 D:HIS254 3.2 30.9 1.0
CD2 D:HIS254 3.4 34.0 1.0
CD2 C:HIS93 3.5 56.9 1.0
OD1 D:ASP283 4.1 68.3 1.0
ND1 C:HIS93 4.4 59.6 1.0
ND1 D:HIS254 4.4 13.5 1.0
CG D:HIS254 4.5 29.6 1.0
CG C:HIS93 4.5 55.0 1.0
CB D:SER252 5.0 50.8 1.0

Nickel binding site 5 out of 5 in 1e0o

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Nickel binding site 5 out of 5 in the Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 5 of Crystal Structure of A Ternary FGF1-FGFR2-Heparin Complex within 5.0Å range:
probe atom residue distance (Å) B Occ
D:Ni404

b:54.5
occ:1.00
O D:HOH504 2.1 81.5 1.0
OD1 D:ASP247 2.1 41.7 1.0
NE2 D:HIS245 2.4 65.2 1.0
CG D:ASP247 2.9 47.0 1.0
OD2 D:ASP247 2.9 43.5 1.0
CE1 D:HIS245 3.0 65.5 1.0
CD2 D:HIS245 3.5 64.0 1.0
ND1 D:HIS245 4.2 57.9 1.0
CB D:ASP247 4.3 38.8 1.0
O D:LEU246 4.5 50.3 1.0
CG D:HIS245 4.5 58.7 1.0
NH2 C:ARG37 4.8 0.6 1.0
CA D:ASP247 4.9 40.9 1.0

Reference:

L.Pellegrini, D.F.Burke, F.Von Delft, B.Mulloy, T.L.Blundell. Crystal Structure of Fibroblast Growth Factor Receptor Ectodomain Bound to Ligand and Heparin Nature V. 407 1029 2000.
ISSN: ISSN 0028-0836
PubMed: 11069186
DOI: 10.1038/35039551
Page generated: Wed Dec 16 01:11:27 2020

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