Nickel »
PDB 3a1f-3ds9 »
3cj2 »
Nickel in PDB 3cj2: Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments
Enzymatic activity of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments
All present enzymatic activity of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments:
2.7.7.48;
2.7.7.48;
Protein crystallography data
The structure of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments, PDB code: 3cj2
was solved by
C.Kissinger,
with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:
| Resolution Low / High (Å) | N/A / 1.75 |
| Space group | P 1 21 1 |
| Cell size a, b, c (Å), α, β, γ (°) | 56.217, 86.133, 120.270, 90.00, 96.54, 90.00 |
| R / Rfree (%) | 21 / 26 |
Other elements in 3cj2:
The structure of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments also contains other interesting chemical elements:
| Bromine | (Br) | 2 atoms |
Nickel Binding Sites:
The binding sites of Nickel atom in the Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments
(pdb code 3cj2). This binding sites where shown within
5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments, PDB code: 3cj2:
Jump to Nickel binding site number: 1; 2;
In total 2 binding sites of Nickel where determined in the Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments, PDB code: 3cj2:
Jump to Nickel binding site number: 1; 2;
Nickel binding site 1 out of 2 in 3cj2
Go back to
Nickel Binding Sites List in 3cj2
Nickel binding site 1 out
of 2 in the Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 1 of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments within 5.0Å range:
|
Nickel binding site 2 out of 2 in 3cj2
Go back to
Nickel Binding Sites List in 3cj2
Nickel binding site 2 out
of 2 in the Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments
Mono view
Stereo pair view
Mono view
Stereo pair view
A full contact list of Nickel with other atoms in the Ni binding
site number 2 of Crystal Structure of Hepatitis C Virus Rna-Dependent Rna Polymerase NS5B in Complex with Optimized Small Molecule Fragments within 5.0Å range:
|
Reference:
S.S.Antonysamy,
B.Aubol,
J.Blaney,
M.F.Browner,
A.M.Giannetti,
S.F.Harris,
N.Hebert,
J.Hendle,
S.Hopkins,
E.Jefferson,
C.Kissinger,
V.Leveque,
D.Marciano,
E.Mcgee,
I.Najera,
B.Nolan,
M.Tomimoto,
E.Torres,
T.Wright.
Fragment-Based Discovery of Hepatitis C Virus NS5B Rna Polymerase Inhibitors. Bioorg.Med.Chem.Lett. V. 18 2990 2008.
ISSN: ISSN 0960-894X
PubMed: 18400495
DOI: 10.1016/J.BMCL.2008.03.056
Page generated: Wed Oct 9 17:13:48 2024
ISSN: ISSN 0960-894X
PubMed: 18400495
DOI: 10.1016/J.BMCL.2008.03.056
Last articles
Zn in 9JPJZn in 9JP7
Zn in 9JPK
Zn in 9JPL
Zn in 9GN6
Zn in 9GN7
Zn in 9GKU
Zn in 9GKW
Zn in 9GKX
Zn in 9GL0
