Atomistry » Nickel » PDB 3dse-3hy3 » 3vja
Atomistry »
  Nickel »
    PDB 3dse-3hy3 »
      3vja »

Nickel in PDB 3vja: Crystal Structure of the Human Squalene Synthase

Enzymatic activity of Crystal Structure of the Human Squalene Synthase

All present enzymatic activity of Crystal Structure of the Human Squalene Synthase:
2.5.1.21;

Protein crystallography data

The structure of Crystal Structure of the Human Squalene Synthase, PDB code: 3vja was solved by C.I.Liu, W.Y.Jeng, W.J.Chang, A.H.J.Wang, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å) 24.50 / 1.76
Space group P 1 21 1
Cell size a, b, c (Å), α, β, γ (°) 52.008, 82.341, 77.175, 90.00, 91.57, 90.00
R / Rfree (%) 16.5 / 23.3

Nickel Binding Sites:

The binding sites of Nickel atom in the Crystal Structure of the Human Squalene Synthase (pdb code 3vja). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Crystal Structure of the Human Squalene Synthase, PDB code: 3vja:
Jump to Nickel binding site number: 1; 2;

Nickel binding site 1 out of 2 in 3vja

Go back to Nickel Binding Sites List in 3vja
Nickel binding site 1 out of 2 in the Crystal Structure of the Human Squalene Synthase


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Crystal Structure of the Human Squalene Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
A:Ni401

b:30.5
occ:1.00
ND1 A:HIS98 2.2 22.6 1.0
CE1 A:HIS98 3.0 23.8 1.0
CG A:HIS98 3.3 23.6 1.0
CB A:HIS98 3.7 26.0 1.0
NE2 A:HIS98 4.2 22.3 1.0
O A:HOH947 4.3 51.6 1.0
CD2 A:HIS98 4.4 23.4 1.0
CG1 A:VAL94 4.8 22.6 1.0

Nickel binding site 2 out of 2 in 3vja

Go back to Nickel Binding Sites List in 3vja
Nickel binding site 2 out of 2 in the Crystal Structure of the Human Squalene Synthase


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Crystal Structure of the Human Squalene Synthase within 5.0Å range:
probe atom residue distance (Å) B Occ
B:Ni401

b:41.1
occ:1.00
ND1 B:HIS98 2.0 28.8 1.0
O B:HOH451 2.3 39.0 1.0
CE1 B:HIS98 2.9 27.6 1.0
CG B:HIS98 3.1 27.3 1.0
CB B:HIS98 3.5 28.0 1.0
NE2 B:HIS98 4.1 27.7 1.0
CD2 B:HIS98 4.2 26.3 1.0
CG1 B:VAL94 4.7 29.9 1.0

Reference:

C.I.Liu, W.Y.Jeng, W.J.Chang, T.P.Ko, A.H.J.Wang. Binding Modes of Zaragozic Acid A to Human Squalene Synthase and Staphylococcal Dehydrosqualene Synthase J.Biol.Chem. V. 287 18750 2012.
ISSN: ISSN 0021-9258
PubMed: 22474324
DOI: 10.1074/JBC.M112.351254
Page generated: Fri Sep 25 08:36:34 2020
© Copyright 2008-2020 by atomistry.com
Home   |    Site Map   |    Copyright   |    Contact us   |    Privacy