Nickel in PDB 8g6t: Bromodomain of Cbp Liganded with Inhibitor ICBP2

All present enzymatic activity of Bromodomain of Cbp Liganded with Inhibitor ICBP2:
2.3.1.48;

The structure of Bromodomain of Cbp Liganded with Inhibitor ICBP2, PDB code: 8g6t was solved by E.Schonbrunn, M.Bikowitz, with X-Ray Crystallography technique. A brief refinement statistics is given in the table below:

Resolution Low / High (Å)	33.65 / 1.75
Space group	P 1
Cell size a, b, c (Å), α, β, γ (°)	34.58, 55.91, 69.67, 93.06, 103.16, 106.53
R / Rfree (%)	19 / 22.2

The structure of Bromodomain of Cbp Liganded with Inhibitor ICBP2 also contains other interesting chemical elements:

Bromine

(Br)

8 atoms

The binding sites of Nickel atom in the Bromodomain of Cbp Liganded with Inhibitor ICBP2 (pdb code 8g6t). This binding sites where shown within 5.0 Angstroms radius around Nickel atom.
In total 2 binding sites of Nickel where determined in the Bromodomain of Cbp Liganded with Inhibitor ICBP2, PDB code: 8g6t:
Jump to Nickel binding site number: 1; 2;

Nickel binding site 1 out of 2 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 1 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range: probe atom residue distance (Å) B Occ C:Ni1202 b:69.3 occ:1.00 O C:HOH1312 1.9 16.0 1.0 OD1 C:ASP1127 2.7 36.1 1.0 OD2 C:ASP1127 2.9 41.1 1.0 CG C:ASP1127 3.2 32.4 1.0 CB C:ASP1127 4.7 27.9 1.0

Nickel binding site 2 out of 2 in the Bromodomain of Cbp Liganded with Inhibitor ICBP2


Mono view


Stereo pair view

A full contact list of Nickel with other atoms in the Ni binding site number 2 of Bromodomain of Cbp Liganded with Inhibitor ICBP2 within 5.0Å range: probe atom residue distance (Å) B Occ D:Ni1202 b:44.7 occ:1.00 OD1 D:ASP1127 2.2 29.8 1.0 O D:HOH1355 2.4 35.5 1.0 O D:HOH1379 2.5 31.2 1.0 O D:HOH1366 2.6 36.6 1.0 O D:HOH1387 2.8 38.0 1.0 CG D:ASP1127 2.9 27.5 1.0 OD2 D:ASP1127 2.9 32.2 1.0 CB D:ASP1127 4.3 23.1 1.0 O D:PRO1123 4.9 26.7 1.0 CA D:ASP1127 5.0 24.6 1.0

E.Schonbrunn, M.Bikowitz. Group 3 Medulloblastoma Transcriptional Networks Are Sensitive to EP300/Cbp Bromodomain Inhibition To Be Published.